@ Steve
I share the same opinion. Researchers try desperately to convince us of the positive effects of these transcriptional activators, but they just ignore that not everything is good.
For example it has been shown that:
- PGC-1 members can also cause muscle atrophy when too high
- induce insulin resistance when too high
- promote lipid accumulation in non-adipose tissue
- cause inflammatory responses.
The link between PGC-1 {alpha} and {beta} and inflammation is pretty new, but very worrying. Olesen et al have shown that PGC-1 is highly proinflammatory at basal states and it is even much worse after induction of further inflammation by Lipopolysaccharide (LPS). There is increase in muscle tumor necrosis factor {alpha} (TNF {alpha} expression in muscle and increase in TNF release into to plasma!
other groups report similar problems. They show that although p65 (NF {kappa} B is lower when PGC-1 is high, but on the other hand TNF is much higher. When TNF or LPS are injected into the muscle the levels of TNF production and release even increase further (positive feedback).
Then also when PGC-1 levels are high, there is a high Interleukin (IL) production. Like IL-6. Markers of macrophage infiltration like cluster of differentiation (CDxx) are elevated.
Altogether PGC-1 has positive effects, but researchers should not hide all negative impacts.